Register below to join the event
Neuromuscular Rehabilitation and ALS Recovery: An Update on Tofersen for SOD1 ALS and Broader Implications for ALS Treatments
May 28, 2025 | 4PM PT, 7PM ET
Dr. Sean E. Smith, MD, MPHS
Assistant Professor of Neurology
Neuromuscular Section
Washington University School of Medicine in St. Louis
Dr. Sean E. Smith is a board-certified physiatrist with specialized training in neuromuscular disorders. He holds the position of Assistant Professor of Neurology in the Neuromuscular Division at the Washington University School of Medicine in St. Louis.
Following his cum laude graduation from the University of Delaware in 2003 with a degree in Nutritional Sciences, Dr. Smith pursued a master’s degree in Exercise Nutrition at the University at Buffalo in 2009. He subsequently obtained his medical degree from Saint Louis University School of Medicine in 2015.
Completing a residency in Physical Medicine and Rehabilitation at Washington University/Barnes-Jewish Hospital, Dr. Smith further advanced his education with a master’s degree in Population Health Sciences (MPHS) in 2020 from Washington University.
In 2021, Dr. Smith completed a fellowship in Neuromuscular Medicine at Washington University/Barnes-Jewish Hospital. Notably, he was the inaugural ALS Clinical Trials Fellow in 2022 under the mentorship of Drs. Timothy Miller and Robert Bucelli, co-directors of the ALS Center at Washington University.
Currently, Dr. Smith holds the leadership role as director of both the WashU ALS Clinic and the Tofersen Clinic. He brings his expertise in rehabilitation medicine to the multidisciplinary ALS care continuum focusing on care coordination, symptom management, and optimizing patient functional independence and mobility. He serves as an investigator in several high impact clinical studies focusing on innovative treatments using antisense oligonucleotides in different types of ALS and other novel therapeutic strategies.
Dr. Beth Hughes, PT, DPT
Board Certified Neurologic Clinical Specialist
Assistant Professor, Washington University Program in Physical Therapy
Beth Hughes, PT, DPT, NCS is an Assistant Professor at the Washington University Program in Physical Therapy. She earned her Bachelor of Science degree in Exercise Physiology in 2016, followed by her Doctorate in Physical Therapy in 2018, both from Saint Louis University. Dr. Hughes has extensive experience in both outpatient and inpatient neurologic rehabilitation and achieved Board Certification as a Neurological Clinical Specialist in 2022.
In her current role, she practices in outpatient neurologic care to a diverse range of patient populations and is the principle physical therapist within the integrated, multidisciplinary ALS clinic at Washington University School of Medicine. Dr. Hughes teaches within the neurologic content at Washington University Program in Physical therapy.
Dr. Hughes is currently focusing her scholarship on advancing knowledge translation and
rehabilitation to improve quality of care within the ALS community. She is dedicated to
advancing the integration of clinical care, education, and evidence-based practices in the
treatment of neurological disorders, with a deep commitment to improving patient outcomes.
_edited.png)